高校问答南京园林局局长:求助翻译高手!!
来源：百度文库 编辑：高校问答 时间：2024/05/01 08:26:16
But obesity in this model is modest ,especially when compared to the phenotype of mice lacking MC4orleptinreceptors.Therecentfindingthatleptinincreasesserotonin turnover112 raises the possibility that at least some of leptin’s weight-reducing effects are mediated through increased serotonin signalling. However, leptin-induced anorexia is intact in mice lacking
the 5HT2C receptor111, indicating that leptin’s ability to reduce food intake does not require signaling at this receptor subtype.
Aminergic neurotransmitter systems, therefore, exert unambiguous effects on food intake and provide important targets for current approaches to drug treatment of obesity. The role of these systems in energy homeostasis is complex, however, and the hypothesis that they serve as major targets for the action of adiposity signals is not strongly supported.
Therapeutic implications
the 5HT2C receptor111, indicating that leptin’s ability to reduce food intake does not require signaling at this receptor subtype.
Aminergic neurotransmitter systems, therefore, exert unambiguous effects on food intake and provide important targets for current approaches to drug treatment of obesity. The role of these systems in energy homeostasis is complex, however, and the hypothesis that they serve as major targets for the action of adiposity signals is not strongly supported.
Therapeutic implications
但肥胖病在这个模型普通, 特别是当与老鼠表现型比较缺乏MC4.orleptinreceptors.Therecentfindingthatleptinincreasesserotonin turnover112 培养可能性, 至少一些leptin 的重量减少的作用被斡旋通过增加的5-羟色胺发信号。但是, leptin 导致的厌食是原封的在老鼠缺乏
5HT2C receptor111, 表明, leptin 的能力减少摄食不要求信号在这感受器官子型。
Aminergic 神经传送体系统施加, 因此, 对摄食的毫不含糊的作用和为当前的方法提供重要目标对肥胖病的药物治疗。这些系统的角色在能量homeostasis 是复杂的, 然而, 和他们起主要目标作用对于adiposity 信号的行动的假说不强烈支持。
治疗涵义
但是这一个模型的肥胖是谦逊的 , 尤其当与老鼠的显型缺乏的 MC4orleptinreceptors 相较。Therecentfindingthatleptinincreasesserotonin turnover112 举起可能性，至少一些 leptin's 的减少重量的效果透过增加的含于血液中的复合月安作信号被斡旋. 然而，感应 leptin 的食欲减退是尚未被人碰过的在老鼠中缺乏的 5 HT2C receptor111, 指出减少食物摄?? leptin's 的能力不需要在这一个受容器次类型作信号.
Aminergic neurotransmitter 系统，因此，发挥在食物摄取上的不含糊的效果而且提供重要的目标给现在的方法下药肥胖的治疗. 然而, 这些系统在能源体内平衡的角色是合成物，而且他们为脂肪过多的行动视为主要的目标信号的假设不强烈被支援.
治疗的含意